Felicity Huffman: (after sharing a dressing room with Madonna in the 80s) I was like, ‘This is Madonna’s underwear! So I tried it on – of course, it didn’t fit me.

Felicity Huffman: I’ve always had a 40-year-old body, and now that I’m actually there I’m like, ‘Hey, pretty good, huh?’

Felicity Huffman: (talking about her husband helping her if she is stuck with a scene) Well, he wouldn’t walk me through it, not that I would mind being walked through anything by William H. Macy. I would fax him changes and the call sheets, so he knew what was coming up. And there were many scenes where I thought, you know, ‘I’m lost; I’m in the weeds!’ and he would break it down or give me ideas. And it’s kind of amazing, you know; it’s kind of like having Tiger Woods in your back pocket.

Felicity Huffman: (talking about her performances) When I am frightened I am a little bit feisty so there are times I say, ‘Why!? Why do you want me to do that!? No! I am not gonna do that!!’

Felicity Huffman: (on her performance in “Transamerica”) Transamerica has been a dream come true because I knew that it was a great acting challenge and I was scared to death every day we shot.

Felicity Huffman: (on her husband’s opinion about “Desperate Housewives”) He feels great about it, and he loves the show and I have a job for the next couples of years, so he is like ‘You go honey, I am gonna garden.’

Felicity Huffman: (on co-writing “A Practical Handbook for the Boyfriend” with Patricia Wolff) We’ve been best friends for 20 years, and we’ve always had these big conversations that revolve around men. When you have children, you stop seeing your girlfriends as much, so this project was great.

Felicity Huffman: I was bulimic and anorexic for a while, just hating my body, As an actress, I was never thin enough, never pretty enough, My boobs weren’t big enough. I was throwing up all the time — figuring out what foods you can throw up and what foods you can’t.

Felicity Huffman: I don’t know if I’m a good mother, You’re not there enough or you’re not patient enough or I’m there enough. I don’t know if I’m patient enough, though, you know, I don’t know if I’m teaching them the right things.

Felicity Huffman: (on the set of “Transamerica”) Towards the end of filming, I walked into the ladies room in full regalia and went Wow, I’m not supposed to be here and I walked out, Then I said Oh no, I am and walked back in again. It took me twice before I said ‘OK, I’m actually a woman and walked into the ladies room. That was sort of frightening.

Felicity Huffman: There are a lot of gay characters on TV now and in movies, and that’s good, but who else can we include? To take an icon like the American cowboy [as Brokeback Mountain does] and go, ‘By the way, they’re gay’, is just great.

Felicity Huffman: In the new millennium, we’re fighting against the icon of the perfect mother…You can complain about your job, you can complain about your husband, you can complain about your friends, but God forbid you complain about your kids.

Felicity Huffman: I’m not the greatest mother – I find motherhood really challenging, and really exhausting, and really frustrating. I feel like I go from one mistake to another.

Felicity Huffman: (on the prosthetic penis she wore for her role in “Transamerica”) Having it in your pants is really different. Because all your focus goes there. It’s like this thing, dangling, which takes all of your attention. It’s no wonder that it’s all they think about.

Felicity Huffman: (about aging gracefully) Everything heads south and you become less and less attractive, but one of the perks is that you can learn to come home to yourself. You’re a little more comfortable in your skin, as saggy as it is.